Toward the development of portable light emitting diode-based polarization spectroscopy tools for breast cancer diagnosis

Kamal, AM and Pal, UM and Kumar, A and Das, GR and Pandya, HJ (2022) Toward the development of portable light emitting diode-based polarization spectroscopy tools for breast cancer diagnosis. In: Journal of Biophotonics, 15 (3).

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Abstract

A robust, affordable and portable light emitting diode-based diagnostic tools (POLS-NIRDx) using a polarization-sensitive (linear as well as circular polarization) technique were designed and developed to quantify the degree of linear polarization (DOLP), degree of circular polarization (DOCP). The study was performed on malignant (invasive ductal carcinoma) and adjacent normal ex-vivo biopsy tissues excised from N = 10 patients at the operating wavelengths of 850 and 940 nm. The average DOLP and DOCP values were lower for malignant than adjacent normal while operating at 850 and 940 nm. The highest accuracy was observed for DOLP (100) and DOCP (80) while operating at 850 nm, which reduced (80 for DOLP and 65 for DOCP) at 940 nm. This pilot study can be utilized as a differentiating factor to delineate malignant tissues from adjacent normal tissues. © 2021 Wiley-VCH GmbH.

Item Type:	Journal Article
Publication:	Journal of Biophotonics
Publisher:	John Wiley and Sons Inc
Additional Information:	The copyright for this article belongs to the John Wiley and Sons Inc.
Keywords:	Biopsy; Diseases; Histology; Light emitting diodes; Light polarization; Tissue, Biopsy tissues; Breast Cancer; Breast cancer diagnosis; Circularly polarized light; Degree of circular polarization; Degree of linear polarization; Lightemitting diode; Linear polarized light; Polarization spectroscopy; Stokes parameters, Circular polarization
Department/Centre:	Division of Electrical Sciences > Electronic Systems Engineering (Formerly Centre for Electronic Design & Technology)
Date Deposited:	04 Jan 2022 05:49
Last Modified:	16 Jun 2022 07:03
URI:	https://eprints.iisc.ac.in/id/eprint/70867

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