Maiti, B and Bhattacharya, S (2022) Liposomal nanoparticles based on steroids and isoprenoids for nonviral gene delivery. In: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 14 (1).
Full text not available from this repository.Abstract
Natural lipid molecules are an essential part of life as they constitute the membrane of cells and organelle. In most of these cases, the hydrophobicity of natural lipids is contributed by alkyl chains. Although natural lipids with a nonfatty acid hydrophobic backbone are quite rare, steroids and isoprenoids have been strong candidates as part of a lipid. Over the years, these natural molecules (steroid and isoprenoids) have been used to make either lipid-based nanoparticle or functionalize in such a way that it could form nano assembly alone for therapeutic delivery. Here we mainly focus on the synthetic functionalized version of these natural molecules which forms cationic liposomal nanoparticles (LipoNPs). These cationic LipoNPs were further used to deliver various negatively charged genetic materials in the form of pDNA, siRNA, mRNA (nucleic acids), and so on. This article is categorized under: Biology-Inspired Nanomaterials > Lipid-Based Structures.
| Item Type: | Journal Article |
|---|---|
| Publication: | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology |
| Publisher: | John Wiley and Sons Inc |
| Additional Information: | The copyright for this article belongs to the John Wiley and Sons Inc. |
| Keywords: | Gene transfer; Genes; Hydrophobicity; Nanoparticles; Nucleic acids, Alkyl chain; Cationics; Gene Delivery; Hydrophobics; Isoprenoids; Lipid molecules; Liposomal nanoparticles; Nano-assemblies; Natural lipids; Non-viral gene delivery, Lipids |
| Department/Centre: | Division of Chemical Sciences > Organic Chemistry |
| Date Deposited: | 17 Nov 2021 10:21 |
| Last Modified: | 08 Jul 2022 05:15 |
| URI: | https://eprints.iisc.ac.in/id/eprint/70512 |
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