Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes

Karunakaran, KB and Amemori, S and Balakrishnan, N and Ganapathiraju, MK and Amemori, K-I (2021) Generalized and social anxiety disorder interactomes show distinctive overlaps with striosome and matrix interactomes. In: Scientific Reports, 11 (1).

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Abstract

Mechanisms underlying anxiety disorders remain elusive despite the discovery of several associated genes. We constructed the protein�protein interaction networks (interactomes) of six anxiety disorders and noted enrichment for striatal expression among common genes in the interactomes. Five of these interactomes shared distinctive overlaps with the interactomes of genes that were differentially expressed in two striatal compartments (striosomes and matrix). Generalized anxiety disorder and social anxiety disorder interactomes showed exclusive and statistically significant overlaps with the striosome and matrix interactomes, respectively. Systematic gene expression analysis with the anxiety disorder interactomes constrained to contain only those genes that were shared with striatal compartment interactomes revealed a bifurcation among the disorders, which was influenced by the anterior cingulate cortex, nucleus accumbens, amygdala and hippocampus, and the dopaminergic signaling pathway. Our results indicate that the functionally distinct striatal pathways constituted by the striosome and the matrix may influence the etiological differentiation of various anxiety disorders. © 2021, The Author(s).

Item Type:	Journal Article
Publication:	Scientific Reports
Publisher:	Nature Research
Additional Information:	The copyright for this article belongs to Authors
Department/Centre:	Division of Interdisciplinary Sciences > Supercomputer Education & Research Centre
Date Deposited:	03 Dec 2021 08:36
Last Modified:	03 Dec 2021 08:36
URI:	http://eprints.iisc.ac.in/id/eprint/70238

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