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RAFT polymerization mediated core-shell supramolecular assembly of PEGMA-co-stearic acid block co-polymer for efficient anticancer drug delivery

Sarkar, P and Ghosh, S and Saha, R and Sarkar, K (2021) RAFT polymerization mediated core-shell supramolecular assembly of PEGMA-co-stearic acid block co-polymer for efficient anticancer drug delivery. In: RSC Advances, 11 (28). pp. 16913-16923.

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Official URL: https://doi.org/10.1039/d1ra01660a

Abstract

In this work, core-shell supramolecular assembly polymeric nano-architectures containing hydrophilic and hydrophobic segments were synthesizedviareversible addition fragmentation chain transfer (RAFT) polymerization. Herein, polyethylene glycol methyl ether methacrylate (PEGMA), and stearic acid were used to synthesize the poly(PEGMA) homopolymer and stearyl ethyl methacrylate (SEMA), respectively. Then, PEGMA and SEMA were polymerized through controlled RAFT polymerization to obtain the final diblock copolymer, poly(PEGMA-co-SEMA) (BCP). Model anticancer drug, doxorubicin (DOX) was loaded on BCPs. Interestingly, efficient DOX release was observed at acidic pH, similar to the cancerous environment pH level. Significant cellular uptake of DOX loaded BCP50 (BCP50-DOX) was observed in MDA-MB-231 triple negative breast cancer cells and resulted in a 35 fold increase in anticancer activity against MDA MB-231 cells compared to free DOX. Scanning electron microscopy (SEM) imaging confirmed the apoptosis mediated cellular death. These core-shell supramolecular assembly polymeric nano-architectures may be an efficient anti-cancer drug delivery system in the future. © The Royal Society of Chemistry 2021.

Item Type: Journal Article
Publication: RSC Advances
Publisher: Royal Society of Chemistry
Additional Information: The copyright for this article belongs to Authors
Keywords: Cell death; Diseases; Living polymerization; Polymethyl methacrylates; Scanning electron microscopy; Shells (structures); Software architecture; Stearic acid; Supramolecular chemistry; Targeted drug delivery, Addition-fragmentation chain transfers; Anti-cancer drug delivery; Anticancer activities; Ethyl methacrylates; Hydrophilic and hydrophobic; Polyethylene glycol methyl ether methacrylates; Supramolecular assemblies; Triple-negative breast cancers, Controlled drug delivery
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 17 Aug 2021 06:36
Last Modified: 17 Aug 2021 06:36
URI: http://eprints.iisc.ac.in/id/eprint/69179

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