Roy, U and Mugler, A (2021) Intermediate adhesion maximizes migration velocity of multicellular clusters. In: Physical Review E, 103 (3).
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Abstract
Collections of cells exhibit coherent migration during morphogenesis, cancer metastasis, and wound healing. In many cases, bigger clusters split, smaller subclusters collide and reassemble, and gaps continually emerge. The connections between cell-level adhesion and cluster-level dynamics, as well as the resulting consequences for cluster properties such as migration velocity, remain poorly understood. Here we investigate collective migration of one- and two-dimensional cell clusters that collectively track chemical gradients using a mechanism based on contact inhibition of locomotion. We develop both a minimal description based on the lattice gas model of statistical physics and a more realistic framework based on the cellular Potts model which captures cell shape changes and cluster rearrangement. In both cases, we find that cells have an optimal adhesion strength that maximizes cluster migration speed. The optimum negotiates a tradeoff between maintaining cell-cell contact and maintaining configurational freedom, and we identify maximal variability in the cluster aspect ratio as a revealing signature. Our results suggest a collective benefit for intermediate cell-cell adhesion. © 2021 American Physical Society.
| Item Type: | Journal Article |
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| Publication: | Physical Review E |
| Publisher: | American Physical Society |
| Additional Information: | The copyright for this article belongs to Authors |
| Keywords: | Aspect ratio; Cell adhesion; Diseases; Potts model; Statistical Physics; Tissue regeneration, Cancer metastasis; Cell-cell contact; Cellular potts models; Chemical gradients; Cluster rearrangement; Intermediate cells; Lattice gas model; Migration velocity, Cells, article; case report; cell adhesion; cell migration; cell shape; clinical article; contact inhibition; human cell; physics; velocity |
| Department/Centre: | Division of Interdisciplinary Sciences > Centre for Biosystems Science and Engineering |
| Date Deposited: | 10 Aug 2021 11:40 |
| Last Modified: | 10 Aug 2021 11:40 |
| URI: | http://eprints.iisc.ac.in/id/eprint/69117 |
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