Shetty, S and Varshney, U (2021) Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles. In: Journal of Biological Chemistry, 296 .
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Abstract
The capacity to modulate gene expression to enhance their fitness to survive and grow in response to changing intracellular and extracellular conditions is one of the most fascinating features of the biological systems. Translation of mRNAs is a major determinant of the changes in the cellular proteome and its downstream effects, which allow the cell to respond to the external factors such as nutrients, temperature, and pH. And, the modulation of the translational apparatus is one of the ways cells employ to rapidly change gene expression. The process of translation occurs in the nexus of both the nucleotides and amino acids, whose production is coupled with the highly conserved one-carbon metabolism (OCM). OCM acts as a central regulator of cellular one-carbon units/ groups (1, 2). The one-carbon units are essential for the synthesis of metabolites including amino acids such as methionine, as well as thymidylate and purines. The impact of OCM on protein synthesis was recognized as early as the 1970s. Similar to the inhibitors of protein synthesis, the inhibitors of OCM are. © 2020 THE AUTHORS.
| Item Type: | Journal Article |
|---|---|
| Publication: | Journal of Biological Chemistry |
| Publisher: | American Society for Biochemistry and Molecular Biology Inc. |
| Additional Information: | The copyright for this article belongs to American Society for Biochemistry and Molecular Biology Inc. |
| Keywords: | Amino acids; Biosynthesis; Gene expression; Metabolism; Metabolites; Proteins, Carbon metabolism; Downstream effects; External factors; Extracellular conditions; One-carbon units; Protein synthesis, Carbon |
| Department/Centre: | Division of Biological Sciences > Microbiology & Cell Biology |
| Date Deposited: | 19 Apr 2021 09:50 |
| Last Modified: | 19 Apr 2021 09:50 |
| URI: | http://eprints.iisc.ac.in/id/eprint/68650 |
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