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Regulation of miR-186-YY1 axis by the p53 translational isoform �40p53: implications in cell proliferation

Katoch, A and Tripathi, SK and Pal, A and Das, S (2021) Regulation of miR-186-YY1 axis by the p53 translational isoform �40p53: implications in cell proliferation. In: Cell Cycle .

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Official URL: https://doi.org/10.1080/15384101.2021.1875670

Abstract

We have earlier shown that p53-FL and its translational isoform �40p53 are differentially regulated. In this study, we have investigated the cellular effect of �40p53 regulation on downstream gene expression, specifically miRNAs. Interestingly, �40p53 showed antagonistic regulation of miR-186-5p as compared to either p53 alone or a combination of both the isoforms. We have elucidated the miR-186-5p mediated effect of �40p53 in cell proliferation. Upon expression of �40p53, we observed a significant decrease in YY1 levels, an established target of miR-186-5p, which is involved in cell proliferation. Further assays with anti-miR-186 established the interdependence of �40p53� miR-186-5p�YY1� cell proliferation. The results unravel a new dimension toward the understanding of �40p53 functions, which seems to regulate cellular fate independent of p53FL. © 2021 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Journal Article
Publication: Cell Cycle
Publisher: Bellwether Publishing, Ltd.
Additional Information: The copyright of this article belongs to Bellwether Publishing, Ltd.
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 12 Mar 2021 15:57
Last Modified: 12 Mar 2021 15:58
URI: http://eprints.iisc.ac.in/id/eprint/68379

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