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Total synthesis of (�)-Cryptofolione

Vaithegi, K and Prasad, KR (2021) Total synthesis of (�)-Cryptofolione. In: Tetrahedron, 79 .

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Official URL: https://dx.doi.org/10.1016/j.tet.2020.131842

Abstract

Enantioselective total synthesis of δ-lactone containing natural product (�)-cryptofolione was accomplished from commercially available benzylidene acetone. Key features of the synthesis include lipase mediated resolution of a β-hydroxy ketone intermediate, DBU mediated isomerization of γ,δ-unsaturated aldehyde to α,β-unsaturated aldehyde, Brown allylation and RCM reactions. © 2020 Elsevier Ltd

Item Type: Journal Article
Publication: Tetrahedron
Publisher: Elsevier Ltd
Additional Information: The copyright of this article belongs to Elsevier Ltd
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 19 Jan 2021 05:30
Last Modified: 19 Jan 2021 05:30
URI: http://eprints.iisc.ac.in/id/eprint/67679

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