Alginate as promising natural polymer for pharmaceutical, food, and biomedical applications

Kothale, D and Verma, U and Dewangan, N and Jana, P and Jain, A and Jain, D (2020) Alginate as promising natural polymer for pharmaceutical, food, and biomedical applications. In: Current Drug Delivery, 17 (9). pp. 755-775.

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Abstract

Alginates are biopolymers usually obtained from brown seaweed, brown algae (Ochrophyta, Phaeophyceae), and bacteria (Azatobacter vineland and Pseudomonas species) belonging to the family of polycationic copolymers. They are biocompatible, biodegradable, non-antigenic, and non-toxic bio-polymer with molecular mass ranges from 32,000-40,000 g/mol in commercial grades. These can be used as edible films or coatings in food industries and also some natural or chemical additives could be incorporated into them to modify their functional, mechanical, nutritional as well as organoleptic properties. Due to their high viscosity and extraordinary shear-thinning effect, they can be used as dietary fibers, thickening, gelling and stabilizing agents. Commercial alginates have vast applications in the fields of biomedical engineering, biotechnology, environmental contaminants treatments, food processing, and pharmaceuticals. Alginates can be used in wound dressings, bone regeneration, neovascularization, protein delivery, cell delivery, theranostic agents, oral drug delivery, controlled release systems, raft formulations, immobilization of biological agents and treatment of environmental contaminants. Various carrier systems can be formulated by the use of alginates like hydrogel, tablets, microcapsules, films, matrices, microspheres, liposomes, nanoparticles, beads, cochleate, floating and supersaturated drug delivery systems. This review presents a broad range of promising applications of alginates, and it can be a great interest to scientists and industries engaged in exploring its hidden potential. © 2020 Bentham Science Publishers.

Item Type:	Journal Article
Publication:	Current Drug Delivery
Publisher:	Bentham Science Publishers
Additional Information:	The copyright of this article belongs to Bentham Science Publishers
Department/Centre:	Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited:	16 Nov 2020 06:46
Last Modified:	16 Nov 2020 06:46
URI:	http://eprints.iisc.ac.in/id/eprint/66705

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