Self-Assembled PtII8Metallosupramolecular Tubular Cage as Dual Warhead Antibacterial Agent in Water

Bhattacharyya, S and Venkateswarulu, M and Sahoo, J and Zangrando, E and De, M and Mukherjee, PS (2020) Self-Assembled PtII8Metallosupramolecular Tubular Cage as Dual Warhead Antibacterial Agent in Water. In: Inorganic Chemistry .

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Abstract

Development of photosensitizer-based self-assembled metallosupramolecular architectures with important applications is an emerging trend in supramolecular chemistry. In this study, we report a new benzothiadiazole-based tetra-pyridyl ligand (L), which upon self-assembly with a cis-block 90° Pt(II) acceptor generated an unprecedented tetrafacial Pt(II)8 photoactive tubular molecular cage (PMB1). This cage could bring an extraordinary photosensitizer, benzothiadiazole, into water which is otherwise insoluble. PMB1 is fluorescent and shows photogeneration of singlet oxygen in an aqueous medium. These features make PMB1 a potent antimicrobial agent in water in both the presence and absence of light. In comparison to its building blocks and water-soluble alkylated charged ligand (LMe44NO3), the cage shows much enhanced photoinduced antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) as a representative of Gram-positive bacteria and Pseudomonas aeruginosa (PA) as a representative of Gram-negative bacteria. PMB1 is successful at inactivating the bacterial growth via both photoactivation of molecular oxygen and membrane depolarization mechanisms, thus proving to be a dual warhead. Inactivation of bacteria in water using such a supramolecular architecture is noteworthy and can shed light on the generation of new antimicrobial supramolecular systems. © 2020 American Chemical Society.

Item Type:	Journal Article
Publication:	Inorganic Chemistry
Publisher:	American Chemical Society
Additional Information:	The copyright of this article belongs to American Chemical Society
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry Division of Chemical Sciences > Organic Chemistry
Date Deposited:	05 Oct 2020 10:32
Last Modified:	05 Oct 2020 10:32
URI:	http://eprints.iisc.ac.in/id/eprint/66548

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