Backbone charge transport in double-stranded DNA

Zhuravel, R and Huang, H and Polycarpou, G and Polydorides, S and Motamarri, P and Katrivas, L and Rotem, D and Sperling, J and Zotti, LA and Kotlyar, AB and Cuevas, JC and Gavini, V and Skourtis, SS and Porath, D (2020) Backbone charge transport in double-stranded DNA. In: Nature Nanotechnology .

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Abstract

Understanding charge transport in DNA molecules is a long-standing problem of fundamental importance across disciplines1,2. It is also of great technological interest due to DNA�s ability to form versatile and complex programmable structures. Charge transport in DNA-based junctions has been reported using a wide variety of set-ups2�4, but experiments so far have yielded seemingly contradictory results that range from insulating5�8 or semiconducting9,10 to metallic-like behaviour11. As a result, the intrinsic charge transport mechanism in molecular junction set-ups is not well understood, which is mainly due to the lack of techniques to form reproducible and stable contacts with individual long DNA molecules. Here we report charge-transport measurements through single 30-nm-long double-stranded DNA (dsDNA) molecules with an experimental set-up that enables us to address individual molecules repeatedly and to measure the current�voltage characteristics from 5 K up to room temperature. Strikingly, we observed very high currents of tens of nanoamperes, which flowed through both homogeneous and non-homogeneous base-pair sequences. The currents are fairly temperature independent in the range 5�60 K and show a power-law decrease with temperature above 60 K, which is reminiscent of charge transport in organic crystals. Moreover, we show that the presence of even a single discontinuity (�nick�) in both strands that compose the dsDNA leads to complete suppression of the current, which suggests that the backbones mediate the long-distance conduction in dsDNA, contrary to the common wisdom in DNA electronics2�4. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.

Item Type:	Journal Article
Publication:	Nature Nanotechnology
Publisher:	Nature Research
Additional Information:	The copyright of this article belongs to Nature Research
Keywords:	Carrier transport, Base pair sequences; Charge transport mechanisms; Double stranded DNA; Double-stranded DNA (ds-DNA); Experimental set up; Temperature independents; Transport measurements; Voltage characteristics, DNA
Department/Centre:	Division of Interdisciplinary Sciences > Computational and Data Sciences
Date Deposited:	03 Sep 2020 11:10
Last Modified:	03 Sep 2020 11:10
URI:	http://eprints.iisc.ac.in/id/eprint/66452

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