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The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response

Seifert, Leon Louis and Si, Clara and Saha, Debjani and Sadic, Mohammad and de Vries, Maren and Ballentine, Sarah and Briley, Aaron and Wang, Guojun and Valero-Jimenez, Ana M and Mohamed, Adil and Schaefer, Uwe and Moulton, Hong M and Garcia-Sastre, Adolfo and Tripathi, Shashank and Rosenberg, Brad R and Dittmann, Meike (2019) The ETS transcription factor ELF1 regulates a broadly antiviral program distinct from the type I interferon response. In: PLOS PATHOGENS, 15 (11).

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Official URL: https://dx.doi.org/10.1371/journal.ppat.1007634

Abstract

Induction of vast transcriptional programs is a central event of innate host responses to viral infections. Here we report a transcriptional program with potent antiviral activity, driven by E74-like ETS transcription factor 1 (ELF1). Using microscopy to quantify viral infection over time, we found that ELF1 inhibits eight diverse RNA and DNA viruses after multi-cycle replication. Elf1 deficiency results in enhanced susceptibility to influenza A virus infections in mice. ELF1 does not feed-forward to induce interferons, and ELF1's antiviral effect is not abolished by the absence of STAT1 or by inhibition of JAK phosphorylation. Accordingly, comparative expression analyses by RNA-seq revealed that the ELF1 transcriptional program is distinct from interferon signatures. Thus, ELF1 provides an additional layer of the innate host response, independent from the action of type I interferons.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to PUBLIC LIBRARY SCIENCE
Keywords: NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CROHNS-DISEASE; MOLECULAR-MECHANISMS; TARGETED DISRUPTION; STIMULATED GENES; LIGAND-BINDING; ZETA-CHAIN; EXPRESSION; REVEALS
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Biological Sciences > Centre for Infectious Disease Research
Depositing User: Id for Latest eprints
Date Deposited: 10 Jan 2020 08:01
Last Modified: 10 Jan 2020 08:01
URI: http://eprints.iisc.ac.in/id/eprint/64307

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