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Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication

Chakraborty, Jeet and Kanungo, Ajay and Mahata, Tridib and Kumar, Krishna and Sharma, Geetika and Pal, Ritesh and Ahammed, Khondakar Sayef and Patra, Dipendu and Majhi, Bhim and Chakrabarti, Saikat and Das, Saumitra and Dutta, Sanjay (2019) Quinoxaline derivatives disrupt the base stacking of hepatitis C virus-internal ribosome entry site RNA: reduce translation and replication. In: CHEMICAL COMMUNICATIONS, 55 (93). pp. 14027-14030.

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Official URL: https://dx.doi.org/10.1039/c9cc06531h

Abstract

RNA-biased small molecules with a monoquinoxaline core target the L-shaped structure of subdomain IIa of Hepatitis C virus internal ribosome entry site (IRES) RNA in proximity to the Mg2+ binding site. The binding event leads to the destacking of RNA bases, resulting in the inhibition of IRES-mediated translation and HCV RNA replication.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to ROYAL SOC CHEMISTRY
Keywords: DOMAIN-II; BINDING; REGION
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 23 Jan 2020 06:11
Last Modified: 23 Jan 2020 06:11
URI: http://eprints.iisc.ac.in/id/eprint/64189

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