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Nucleolus: A Protein Quality Control Compartment

Rekulapally, Pavani and Suresh, S N (2019) Nucleolus: A Protein Quality Control Compartment. In: TRENDS IN BIOCHEMICAL SCIENCES, 44 (12). pp. 993-995.

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Official URL: https://dx.doi.org/10.1016/j.tibs.2019.10.001


Frottin et al. uncovered a role for the nucleolus as a key quality control compartment that regulates misfolded nuclear proteins. This nonmembrane compartment achieves this by forming liquid-like protein condensates that aid protein refolding in a heat-shock protein (Hsp)70-dependent manner. This liquid-liquid phase separation (LLPS)-mediated nuclear quality control mechanism is perturbed during neurodegeneration.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to ELSEVIER SCIENCE LONDON
Department/Centre: Autonomous Societies / Centres > Centre for Brain Research
Depositing User: Id for Latest eprints
Date Deposited: 18 Dec 2019 06:37
Last Modified: 18 Dec 2019 06:37
URI: http://eprints.iisc.ac.in/id/eprint/64037

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