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You Cannot Have Your Synergy and Efficacy Too

Sen, Pramita and Saha, Ananya and Dixit, Narendra M (2019) You Cannot Have Your Synergy and Efficacy Too. In: TRENDS IN PHARMACOLOGICAL SCIENCES, 40 (11). pp. 811-817.

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Official URL: https://dx.doi.org/10.1016/j.tips.2019.08.008

Abstract

Synergistic drugs are preferred in combination therapies for many diseases, including viral infections and cancers. Maximizing synergy, however, may come at the cost of efficacy. This synergy-efficacy trade-off appears to be widely prevalent and independent of the specific drug interactions yielding synergy. We present examples of the trade-off in drug combinations used in hepatitis C, HIV, and cancer therapies and believe that screens for optimal drug combinations that presently seek to maximize synergy may be improved by considering the trade-off.

Item Type: Journal Article
Additional Information: copyright for this article belongs to ELSEVIER SCIENCE LONDON
Department/Centre: Division of Interdisciplinary Research > Centre for Biosystems Science and Engineering
Division of Mechanical Sciences > Chemical Engineering
Depositing User: Id for Latest eprints
Date Deposited: 29 Nov 2019 12:12
Last Modified: 29 Nov 2019 12:12
URI: http://eprints.iisc.ac.in/id/eprint/64015

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