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Translation initiation in mammalian mitochondria- a prokaryotic perspective

Ayyub, Shreya Ahana and Varshney, Umesh (2019) Translation initiation in mammalian mitochondria- a prokaryotic perspective. In: RNA BIOLOGY .

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Official URL: http://doi.org/10.1080/15476286.2019.1690099

Abstract

ATP is generated in mitochondria of eukaryotic cells by oxidative phosphorylation (OXPHOS). The OXPHOS complex, which is crucial for cellular metabolism, comprises of both nuclear and mitochondrially encoded subunits. Also, the occurrence of several pathologies because of mutations in the mitochondrial translation apparatus indicates the importance of mitochondrial translation and its regulation. The mitochondrial translation apparatus is similar to its prokaryotic counterpart due to a common origin of evolution. However, mitochondrial translation has diverged from prokaryotic translation in many ways by reductive evolution. In this review, we focus on mammalian mitochondrial translation initiation, a highly regulated step of translation, and present a comparison with prokaryotic translation.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to TAYLOR & FRANCIS INC
Keywords: TRANSFER-RNA; RIBOSOMAL-PROTEINS; ELONGATION-FACTORS; TERMINAL EXTENSIONS; MESSENGER-RNAS; START-CODON; WEIGHT-LOSS; FACTOR-III; YEAST; MUTATION
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 07 Feb 2020 10:38
Last Modified: 07 Feb 2020 10:38
URI: http://eprints.iisc.ac.in/id/eprint/64000

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