Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid

Gopinatha, Vindya K and Swarup, Hassan A and Raghavan, Sathees C and Mantelingu, Kempegowda and Rangappa, Kanchugarakoppal S (2019) Discovery of Novel Approach for Regioselective Synthesis of Thioxotriaza-Spiro Derivatives via Oxalic Acid. In: SYNLETT, 30 (17). pp. 2004-2009.

PDF Syn_30-17_2009_2019.pdf - Published Version Restricted to Registered users only Download (286kB) | Request a copy

Abstract

A vital approach for the synthesis of a range of novel thioxotriaza-spiro derivatives is described. These new heterocyclic systems are obtained via oxalic acid catalyzed reaction of alpha,beta-unsaturated ketones in the presence of 5,6-diamino-2-mercaptopyrimidine-4-ols; thus, spiro rings are constructed in one step. Notably, this transformation involves condensation of an amino group followed by enamine reaction with alkenes and subsequent reaction promoted by oxalic acid to afford spiro compounds with excellent regioselectivity.

Item Type:	Journal Article
Publication:	SYNLETT
Publisher:	GEORG THIEME VERLAG KG
Additional Information:	Copyright for this article GEORG THIEME VERLAG KG
Keywords:	spiro rings; regioselective; oxalic acid; enamine; NHEJ
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	05 Mar 2020 10:26
Last Modified:	05 Mar 2020 10:26
URI:	http://eprints.iisc.ac.in/id/eprint/63849

Actions (login required)

View Item