Directing Traffic: Halogen-Bond-Mediated Membrane Transport

Govindaraj, Vijayakumar and Ungati, Harinarayana and Jakka, Surendar R and Bose, Sritama and Mugesh, Govindasamy (2019) Directing Traffic: Halogen-Bond-Mediated Membrane Transport. In: CHEMISTRY-A EUROPEAN JOURNAL, 25 (48). pp. 11180-11192.

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Abstract

The plasma membrane regulates the transport of molecules into the cell. Small hydrophobic molecules can diffuse directly across the lipid bilayer. However, larger molecules require specific transporters for their entry into the cell. Regulating the cellular entry of small molecules and proteins is a challenging task. The introduction of halogen, particularly iodine, to small molecules and proteins is emerging to be a promising strategy to improve the cellular uptake. Recent studies reveal that a simple substitution of hydrogen atom with iodine not only increases the cellular uptake, but also regulates the membrane transport. The strong halogen-bond-forming ability of iodine atoms plays a crucial role in the transport and the introduction of iodine may provide an efficient strategy for studying membrane activity and cellular functions and improving the delivery of therapeutic agents. This Concept article does not provide a comprehensive picture of membrane transport but highlights halogen-substitution as a novel strategy for understanding and regulating the cell-membrane traffic.

Item Type:	Journal Article
Publication:	CHEMISTRY-A EUROPEAN JOURNAL
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	copyright for this article belongs to WILEY-V C H VERLAG GMBH
Keywords:	cellular uptake; fluorescent molecules; halogen; MCT8 transporter; thyroid hormones
Department/Centre:	Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited:	22 Oct 2019 06:12
Last Modified:	22 Oct 2019 06:12
URI:	http://eprints.iisc.ac.in/id/eprint/63738

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