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Yeast cytochrome c is a sequence-specific DNA-binding protein

Bhatnagar, Anshu and Raghavendra, Pralhada Rao and Kranthi, Balla V and Rangarajan, Pundi N (2004) Yeast cytochrome c is a sequence-specific DNA-binding protein. In: Biochemical and Biophysical Research Communications, 321 (4). pp. 900-904.

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A protein binding to the alcohol oxidase 2 upstream activation sequence (AOX2UAS) of the methylotropic yeast, Pichia pastoris, has been puri.ed and identi.ed as cytochrome c (cyt c). Cyt c puri.ed from P. pastoris or Saccharomyces cerevisiae binds to AOX2UAS. Speci.c point mutations in AOX2UAS abolish cyt c binding. We conclude that yeast cyt c is a sequence-specific DNA-binding protein and may have a regulatory role in the nucleus.

Item Type: Journal Article
Publication: Biochemical and Biophysical Research Communications
Publisher: Elsevier
Additional Information: The copyright belongs to Elsevier.
Keywords: Pichia pastoris;Transcription;Cytochrome c;Saccharomyces cerevisiae;Alcohol oxidase
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 19 Apr 2006
Last Modified: 19 Sep 2010 04:25
URI: http://eprints.iisc.ac.in/id/eprint/6357

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