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The WNT Framework in Shaping Immune Cell Responses During Bacterial Infections

Mukherjee, Tanushree and Balaji, Kithiganahalli Narayanaswamy (2019) The WNT Framework in Shaping Immune Cell Responses During Bacterial Infections. In: FRONTIERS IN IMMUNOLOGY, 10 .

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Official URL: https://doi.org/10.3389/fimmu.2019.01985


A large proportion of the world is inflicted with health concerns arising from infectious diseases. Moreover, there is a widespread emergence of antibiotic resistance among major infectious agents, partially stemming from their continuous dialog with the host, and their enormous capacity to remodel the latter toward a secure niche. Among the several infection-driven events, moderation of WNT signaling pathway has been identified to be strategically tuned during infections to govern host-pathogen interactions. Primarily known for its role in arbitrating early embryonic developmental events; aberrant activation of the WNT pathway has also been associated with immunological consequences during diverse patho-physiological conditions. Here, we review the different mechanisms by which components of WNT signaling pathways are exploited by discrete bacterial agents for their pathogenesis. Furthermore, recent advances on the cross-talk of WNT with other signaling pathways, the varied modes of WNT-mediated alteration of gene expression, and WNT-dependent post-transcriptional and post-translational regulation of the immune landscape during distinct bacterial infections would be highlighted.

Item Type: Journal Article
Additional Information: Copyright © 2019 Mukherjee and Balaji. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: Wnt; infectious diseases; epigenetics; nuclear Wnt signaling; therapeutics
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 17 Sep 2019 08:55
Last Modified: 22 Oct 2019 17:12
URI: http://eprints.iisc.ac.in/id/eprint/63558

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