Triclosan as a Systemic Antibacterial Agent in a Mouse Model of Acute Bacterial Challenge

Sharma, Shilpi and Ramya, TNC and Surolia, Avadhesha and Surolia, Namita (2003) Triclosan as a Systemic Antibacterial Agent in a Mouse Model of Acute Bacterial Challenge. In: Antimicrobial Agents and Chemotherapy, 47 (12). pp. 3859-3866.

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Abstract

The upsurge of multiple-drug-resistant microbes warrants the development and/or use of effective antibiotics. Triclosan, though used in cosmetic and dermatological preparations for several decades, has not been used as a systemic antibacterial agent due to problems of drug administration. Here we report the striking efficacy of triclosan in a mouse model of acute systemic bacterial infection. Triclosan not only significantly extends the survival time of the infected mice, it also restores blood parameters and checks liver damage induced by the bacterial infection. We believe that the excellent safety track record of triclosan in topical use coupled with our findings qualifies triclosan as a candidate drug or lead compound for exploring its potential in experimental systems for treating systemic bacterial infections.

Item Type:	Journal Article
Publication:	Antimicrobial Agents and Chemotherapy
Publisher:	American Society for Microbiology
Additional Information:	The Copyright belongs to American Society for Microbiology.
Department/Centre:	Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited:	19 Apr 2006
Last Modified:	19 Sep 2010 04:25
URI:	http://eprints.iisc.ac.in/id/eprint/6338

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