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Enantioselective Direct Vinylogous Allylic Alkylation of 4-Methylquinolones under Iridium Catalysis

Sarkar, Rahul and Mukherjee, Santanu (2019) Enantioselective Direct Vinylogous Allylic Alkylation of 4-Methylquinolones under Iridium Catalysis. In: ORGANIC LETTERS, 21 (13). pp. 5315-5320.

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Official URL: https://dx.doi.org/10.1021/acs.orglett.9b01934

Abstract

The first enantioselective vinylogous allylic alkylation of 4-methylquinolones has been developed. This iridium-catalyzed reaction introduces an allyl group at the gamma-position of 4-methyl-2-quinolones with exclusive branched selectivity and an excellent level of enantioselectivity. This in turn allows for the enantioselective synthesis of gamma-allylquinolines and related nitrogenous heterocycles. This is the first application of 4-methylquinolones in an enantioselective transformation.

Item Type: Journal Article
Additional Information: copyright for this article belongs to AMER CHEMICAL SOC
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 22 Aug 2019 10:35
Last Modified: 22 Aug 2019 10:35
URI: http://eprints.iisc.ac.in/id/eprint/63305

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