Cobalt(III)-Catalyzed Direct ortho-Alkenylation of Arylpyrazoles: A Comparative Study on Decarboxylation and Desilylation

Kumar, Anil and Muniraj, Nachimuthu and Prabhu, Kandikere Ramaiah (2019) Cobalt(III)-Catalyzed Direct ortho-Alkenylation of Arylpyrazoles: A Comparative Study on Decarboxylation and Desilylation. In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019 (16). pp. 2735-2739.

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Abstract

A comparative study on Co-III-catalyzed direct C-H bond alkenylation of 1-phenylpyrazole derivatives with alkynyl carboxylic acids and arylalkynylsilanes under redox-neutral conditions has been disclosed. These methods show excellent selectivity with good to excellent yields. Trimethylsilylacetylene has been utilized as a vinyl source to obtain the corresponding styrene derivatives. The major differences between these two reactions are the decarboxylation proceeds in the presence of a base additive whereas the desilylation takes place in the presence of an acid additive. The developed methodologies are compatible with a variety of functional groups.

Item Type:	Journal Article
Publication:	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Publisher:	WILEY-V C H VERLAG GMBH
Additional Information:	Copyright for this article belongs to WILEY-V C H VERLAG GMBH
Keywords:	Earth-abundant metals; Arylpyrazoles; Arylalkynyl carboxylic acids; Cobalt; C-H Activation
Department/Centre:	Division of Chemical Sciences > Organic Chemistry
Date Deposited:	07 Nov 2019 11:08
Last Modified:	07 Nov 2019 11:08
URI:	http://eprints.iisc.ac.in/id/eprint/63245

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