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Cobalt(III)-Catalyzed Direct ortho-Alkenylation of Arylpyrazoles: A Comparative Study on Decarboxylation and Desilylation

Kumar, Anil and Muniraj, Nachimuthu and Prabhu, Kandikere Ramaiah (2019) Cobalt(III)-Catalyzed Direct ortho-Alkenylation of Arylpyrazoles: A Comparative Study on Decarboxylation and Desilylation. In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019 (16). pp. 2735-2739.

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Official URL: https://dx.doi.org/10.1002/ejoc.201900270

Abstract

A comparative study on Co-III-catalyzed direct C-H bond alkenylation of 1-phenylpyrazole derivatives with alkynyl carboxylic acids and arylalkynylsilanes under redox-neutral conditions has been disclosed. These methods show excellent selectivity with good to excellent yields. Trimethylsilylacetylene has been utilized as a vinyl source to obtain the corresponding styrene derivatives. The major differences between these two reactions are the decarboxylation proceeds in the presence of a base additive whereas the desilylation takes place in the presence of an acid additive. The developed methodologies are compatible with a variety of functional groups.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to WILEY-V C H VERLAG GMBH
Keywords: Earth-abundant metals; Arylpyrazoles; Arylalkynyl carboxylic acids; Cobalt; C-H Activation
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 07 Nov 2019 11:08
Last Modified: 07 Nov 2019 11:08
URI: http://eprints.iisc.ac.in/id/eprint/63245

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