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Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes

Malik, Manzoor Ahmad and Raza, Md Kausar and Dar, Ovas Ahmad and Amadudin, Amadudin and Abid, Mohammad and Wani, Mohmmad Younus and Al-Bogami, Abdullah Saad and Hashmi, Athar Adil (2019) Probing the antibacterial and anticancer potential of tryptamine based mixed ligand Schiff base Ruthenium(III) complexes. In: BIOORGANIC CHEMISTRY, 87 . pp. 773-782.

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Official URL: https://doi.org/10.1016/j.bioorg.2019.03.080

Abstract

Development of new chemotherapeutic agents to treat microbial infections and recurrent cancers is of pivotal importance. Metal based drugs particularly ruthenium complexes have the uniqueness and desired properties that make them suitable candidates for the search of potential chemotherapeutic agents. In this study, two mixed ligand Ru(III) complexes Ru(Cl)(2)(SB)(Phen] (RC-1) and Ru(Cl)(2)(SB)(Bipy)] (RC-2) were synthesised and characterized by elemental analysis, IR, UV-Vis, H-1, C-13 NMR spectroscopic techniques and their molecular structure was confirmed by X-ray crystallography. Antibacterial activity evaluation against two Gram-positive (S. pneumonia and E. faecalis) and four Gram-negative strains (P. aurogenosa, K. pneumoniae, S. enterica, and E. coli) revealed their moderate antibacterial activity with MIC value of >= 250 mu g/mL. Anticancer activity evaluation against a non-small lung cancer cell line (H1299) revealed the tremendous anticancer activity of these complexes which was further validated by DNA binding and docking results. DNA binding profile of the complexes studied by UV-Visible and fluorescence spectroscopy showed an intercalative binding mode with CT-DNA and an intrinsic binding constant in the range of 3.481-1.015 x 10(5) M-1. Both the complexes were also found to exert weak toxicity to human erythrocytes by haemolytic assay compared to cisplatin. Potential of these complexes as anticancer agents will be further delineated by in vivo studies.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords: Ru(III) complexes; X-ray crystallography; Antimicrobial; DNA binding; Anticancer; Docking
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 25 Jun 2019 18:07
Last Modified: 25 Jun 2019 18:07
URI: http://eprints.iisc.ac.in/id/eprint/63040

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