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Effect of feeding high fat diet on reproductive parameters in male mice

Samuel, Rosa J and Joy, Omana and Murthy, P Krishna and Iyer, Shruthi and Ramachandra, SG and Thamaraiselvi, K (2019) Effect of feeding high fat diet on reproductive parameters in male mice. In: INDIAN JOURNAL OF ANIMAL RESEARCH, 53 (4). pp. 505-509.

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Official URL: https://doi.org/10.18805/ijar.B-3528


The present study attempts to chronicle the series of changes starting from the consumption of high fat diet till reproductive activity in male mice. A marginal increase in body weight was observed in male mice fed with high fat diet with 3-fold increase in total body fat and 1.4-fold increase in adipose tissue. A significant reduction in number and diameter of seminiferous tubules were observed in high fat diet fed mice compared to control mice. FACS analysis of testicular germ cells revealed very high percentage of apoptotic cells (84%) compared to control animals (2-3 %) indicative of reduced spermatogenic activity. In addition, a significant decrease in litter size (11.6%-Control to 3.66%-HFD) indicates that reproductive efficiency in high fat diet fed mice reduced to a great extent. The present study revealed high fat diet alters the fertility in male mice significantly and the first in this process appears to be apoptosis of testicular cells due to increase in ROS.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to AGRICULTURAL RESEARCH COMMUNICATION CENTRE
Keywords: Apoptosis; High fat diet; Infertility; Obesity; Reproductive failure; Spermatogenesis
Department/Centre: Division of Biological Sciences > Central Animal Facility (Formerly Primate Research Laboratory)
Depositing User: LIS Interns
Date Deposited: 23 May 2019 12:11
Last Modified: 23 May 2019 12:11
URI: http://eprints.iisc.ac.in/id/eprint/62739

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