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Studying the rigidity of red blood cells induced by Plasmodium falciparum infection

Paul, Apurba and Ramdani, Ghania and Tatu, Utpal and Langsley, Gordon and Natarajan, Vasant (2019) Studying the rigidity of red blood cells induced by Plasmodium falciparum infection. In: SCIENTIFIC REPORTS, 9 .

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Official URL: https://dx.doi.org/10.1038/s41598-019-42721-w

Abstract

We study the effect of different chemical moieties on the rigidity of red blood cells (RBCs) induced by Plasmodium falciparum infection, and the bystander effect previously found. The infected cells are obtained from a culture of parasite-infected RBCs grown in the laboratory. The rigidity of RBCs is measured by looking at the Brownian fluctuations of individual cells in an optical-tweezers trap. The results point towards increased intracellular cyclic adenosine monophosphate (cAMP) levels as being responsible for the increase in rigidity.

Item Type: Journal Article
Additional Information: The copyright for this article belongs to the authors
Department/Centre: Division of Biological Sciences > Biochemistry
Division of Physical & Mathematical Sciences > Physics
Depositing User: Ms Ranganayaki RS
Date Deposited: 16 May 2019 11:52
Last Modified: 16 May 2019 11:52
URI: http://eprints.iisc.ac.in/id/eprint/62659

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