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Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells

Kotak, Sachin (2019) Mechanisms of Spindle Positioning: Lessons from Worms and Mammalian Cells. In: BIOMOLECULES, 9 (2).

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Official URL: http://dx.doi.org/ 10.3390/biom9020080


Proper positioning of the mitotic spindle is fundamental for specifying the site for cleavage furrow, and thus regulates the appropriate sizes and accurate distribution of the cell fate determinants in the resulting daughter cells during development and in the stem cells. The past couple of years have witnessed tremendous work accomplished in the area of spindle positioning, and this has led to the emergence of a working model unravelling in-depth mechanistic insight of the underlying process orchestrating spindle positioning. It is evident now that the correct positioning of the mitotic spindle is not only guided by the chemical cues (protein-protein interactions) but also influenced by the physical nature of the cellular environment. In metazoans, the key players that regulate proper spindle positioning are the actin-rich cell cortex and associated proteins, the ternary complex (G alpha/GPR-1/2/LIN-5 in Caenorhabditis elegans, Gi/Pins/Mud in Drosophila and Gi(1-3)/LGN/NuMA in humans), minus-end-directed motor protein dynein and the cortical machinery containing myosin. In this review, I will mainly discuss how the abovementioned components precisely and spatiotemporally regulate spindle positioning by sensing the physicochemical environment for execution of flawless mitosis.

Item Type: Journal Article
Publisher: MDPI
Additional Information: copyright for this article belongs to MDPI
Keywords: mitosis; microtubules; spindle positioning; actin cytoskeleton; NuMA; dynein; myosin
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Date Deposited: 29 May 2019 09:24
Last Modified: 29 May 2019 09:24
URI: http://eprints.iisc.ac.in/id/eprint/62511

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