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Orthogonally clickable hyperbranched polymers: Effect of reactant size and polarity on core-functionalization of peripherally jacketed HBPs

Perala, SK and Ramakrishnan, S. (2019) Orthogonally clickable hyperbranched polymers: Effect of reactant size and polarity on core-functionalization of peripherally jacketed HBPs. In: Polymer Chemistry, 10 (13). pp. 1626-1635.

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Official URL: https://dx.doi.org/10.1039/c8py01499j

Abstract

We describe a strategy for the preparation of an "orthogonally clickable" HB polyester (HBP) via a melt trans-esterification process, starting from a suitably designed AB 2 monomer. The resulting HBP carries an allyl group on each repeat unit within the core-region and numerous propargyl groups on the molecular periphery; selective reaction of the periphery, to yield jacketed HBPs, permitted the examination of various factors that govern the access to internal reactive (allyl) sites. First, either hydrophobic docosyl (C22) or hydrophilic PEG350 segments were quantitatively clicked onto the periphery via the azide-yne reaction; subsequently, access of the internal allyl groups to thiol-ene reaction was examined using organic thiols of varying size and polarity. It was seen that the extent of reaction depends not only on the size of the thiol reactant but also on its relative polarity; for instance, a polar thiol is less effective in accessing the internal allyl groups of a HBP bearing docosyl segments on the periphery when compared to a non-polar thiol of roughly the same size. Likewise, when PEG segments are installed at the periphery, access to more polar reactants is favoured when compared to non-polar analogues of a similar size. These studies provide some interesting insights that could be useful in designing HBP supported catalysts for substrate-selective transformations.

Item Type: Journal Article
Additional Information: The copyright for this article belongs to Royal Society of Chemistry
Keywords: Polymer blends, Functionalizations; Hyperbranched polymers; Organic thiols; Relative polarity; Repeat units; Selective reactions; Selective transformation; Thiol-ene reactions, Dendrimers
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 06 May 2019 17:21
Last Modified: 06 May 2019 17:21
URI: http://eprints.iisc.ac.in/id/eprint/62210

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