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Synthesis, cytotoxic and antioxidant activities of azolyl benzothiazine carboxamides

Panga, SS and Tamatam, R and Adivireddy, P and Venkatapuram, P and Narra, SK and Paturu, K (2019) Synthesis, cytotoxic and antioxidant activities of azolyl benzothiazine carboxamides. In: Research on Chemical Intermediates .

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Abstract

Abstract: Azolyl benzothiazine carboxamides were prepared from benzothiazine carboxylate and azolyl amines in the presence of NaOMe under ultrasonication. 4-Bromothiophenylimidazolyl benzothiazine carboxamide (19b) and 4-bromopyrrolylimidazolyl benzothiazine carboxamide (22b) showed cytotoxic activity on HeLa cell lines (IC 50 33.75, 47.52 µM) and MCF-7 cell lines (IC 50 31.75, 34.35 µM). Furthermore, methyl-substituted furanyloxazolyl benzothiazine carboxamide (14a), furanylimidazolyl benzothiazine carboxamide (16a), thiophenyloxazolyl benzothiazine carboxamide (17a) and pyrrolyloxazolyl benzothiazine carboxamide (20a) exhibited antioxidant activity greater than ascorbic acid. Graphical abstract: Azolyl benzothiazine carboxamides are prepared from benzothiazine carboxylate and azolyl amines. Optimization of reaction conditions is established using different molar concentrations of NaOMe. Compounds 19b and 22b showed cytotoxic activity on HeLa cell lines and MCF-7 cell lines. Compounds 14a, 16a, 17a and 20a exhibited prominent antioxidant activity.Figure not available: see fulltext.. © 2019, Springer Nature B.V.

Item Type: Journal Article
Additional Information: cited By 0
Keywords: Amines; Antioxidants; Ascorbic acid; Carboxylation; Cell culture; Molar concentration, Anti-oxidant activities; Azole; Carboxamides; Cytotoxic activities; Hela cell line; MCF-7 cells; Reaction conditions; Ultra-sonication, Lanthanum compounds
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Depositing User: Id for Latest eprints
Date Deposited: 16 Apr 2019 06:45
Last Modified: 16 Apr 2019 06:45
URI: http://eprints.iisc.ac.in/id/eprint/62111

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