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Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides

Ramkumar, Rajagopal and Chandrasekaran, Srinivasan (2019) Catalyst-Free, Metal-Free, and Chemoselective Transamidation of Activated Secondary Amides. In: SYNTHESIS-STUTTGART, 51 (4). pp. 921-932.

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Official URL: https://doi.org/10.1055/s-0037-1610664


A simple protocol, which is catalyst-free, metal-free, and chemoselective, for transamidation of activated secondary amides in ethanol as solvent under mild conditions is reported. A wide range of amines, amino acids, amino alcohols, and the substituents, which are problematic in catalyzed transamidation, are tolerated in this methodology. The transamidation reaction was successfully extended to water as the medium as well. The present methodology appears to be better than the other catalyzed transamidations reported recently.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Georg Thieme Verlag KG.
Keywords: amino acid; catalyst-free; metal-free; chemoselective; secondary amide; transamidation
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 11 Mar 2019 10:29
Last Modified: 11 Mar 2019 10:29
URI: http://eprints.iisc.ac.in/id/eprint/61949

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