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One-pot synthesis of hydrophilic flower-shaped iron oxide nanoclusters (IONCs) based ferrofluids for magnetic fluid hyperthermia applications

Kandasamy, Ganeshlenin and Khan, Shaheen and Giri, Jyotsnendu and Bose, Suryasarathi and Veerapu, Naga Suresh and Maity, Dipak (2019) One-pot synthesis of hydrophilic flower-shaped iron oxide nanoclusters (IONCs) based ferrofluids for magnetic fluid hyperthermia applications. In: JOURNAL OF MOLECULAR LIQUIDS, 275 . pp. 699-712.

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Official URL: https://doi.org/10.1016/j.molliq.2018.11.108

Abstract

Herein, flower-shaped hydrophilic superparamagnetic iron oxide nanoclusters (IONCs) are synthesized via one pot thermolysis of iron acetylacetonate using triethanolamine (TEA) and diethylene glycol (DEG)/tetraethylene glycol (TTEG) mixtures at 9:1, 8:2 and 7:3 (v/v) ratios. The as-prepared 24-29 nm sized IONCs have displayed (i) saturation magnetization (Ms) values of similar to 68-78 emu/g, (ii) hydrodynamic diameters of similar to 95-192 nm and (iii) zeta potential values of +46 to +65 my. Due to relatively high magnetization and water solubility, IONCs (prepared using 8:2 TEA:DEG, and 8:2 & 7:3 TEA:TrEG ratios) based aqueous ferrofluids i.e. NCAFF-1, NCAFF-2, and NCAFF-3 are investigated by calorimetric magnetic fluid hyperthermia (MFH) at 0.5-8 mg/ml concentrations by exposing them to the alternating magnetic fields (AMFs, H*f similar to 2.4-9.9 GA m(-1) s(-1)). The NCAFF-3 has demonstrated excellent time dependent temperature rise (42 degrees C within 0.7-9.7 min) as compared to the NCAFF-1 and NCAFF-2. Moreover, the NCAFF-3 at 0.5 mg/ml concentration has exhibited enhanced heating efficacies with specific absorption rate (SAR) and intrinsic loss power (ILP) values of 142.4-909.4 W/g(Fe) and 4.2-14.7 nHm(2)/kg, respectively. Furthermore, the NCAFF-3 has presented better cytocompatibility, and substantially reduced proliferation capacity of HepG2 cancer cells in in vitro MFH studies. Thus, the IONCs based ferrofluids (NCAFF-3) are very promising candidates for MFH therapeutics applications. (C) 2018 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Keywords: Flower-shaped magnetic particles; Superparamagnetic iron oxides nanoclusters; Aqueous ferrofluids; Magnetic fluid hyperthermia; Thermotherapy; Biomedical applications
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Id for Latest eprints
Date Deposited: 04 Mar 2019 09:18
Last Modified: 04 Mar 2019 09:18
URI: http://eprints.iisc.ac.in/id/eprint/61885

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