ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

One-step synthesis of hydrophilic functionalized and cytocompatible superparamagnetic iron oxide nanoparticles (SPIONs) based aqueous ferrofluids for biomedical applications

Kandasamy, Ganeshlenin and Soni, Shalini and Sushmita, Kumari and Veerapu, Naga Suresh and Bose, Suryasarathi and Maity, Dipak (2019) One-step synthesis of hydrophilic functionalized and cytocompatible superparamagnetic iron oxide nanoparticles (SPIONs) based aqueous ferrofluids for biomedical applications. In: JOURNAL OF MOLECULAR LIQUIDS, 274 . pp. 653-663.

[img] PDF
Jou_Mol_Liq_274_653_2019.pdf - Published Version
Restricted to Registered users only

Download (3MB) | Request a copy
Official URL: https://doi.org/10.1016/j.molliq.2018.10.16

Abstract

This work systematically describes one-step synthesis of hydrophilic functionalized superparamagnetic iron oxide nanoparticies (SPIONs) via thermolysis in presence of polyamines such as diethylene triamine (DETA), triethylene tetraamine (TETA), tetraethylene pentamine (TTEPA), or pentaethylene hexamine (PEHA) or mixture of a polyamine (TETA) and polyols such as diethylene glycol (DEG), triethylene glycol (TEG) or tetraethylene glycol (TTEG) while varying the polyamine: polyol (v/v) ratio, reaction temperature and reaction time, The saturation magnetization (Ms) values of the as-prepared polyamine (DETA/TETA/TTEPA/PEHA) coated SPIONs are determined in the range of 31.8-48.5 emu/g, which is altered in the range of 40.2-57.8 emu/g by the addition of a polyol (DEG/TEG/TTEG) to the polyamine (TETA) at different ratios. Moreover, the Ms. values are further improved to 64.6 and 66.8 emu/g at the optimized TETA:TEG (1:1) ratio by prolonging the reaction time up-to 2 h and the reaction temperature to 270 degrees C, respectively. In addition, the TETA-TEG coated SPIONs have displayed their average particle sizes, hydrodynamic sizes, and zeta potential (zeta) values in the range of 7-11 nm, 99-120 nm and +45 to +57 mV, respectively (indicating high water solubility). Finally, the TETA-TEG coated SPIONs with the highest Ms. and zeta values (i.e. 66.8 emu/g and +57 my) are selected for the biological studies, where they have revealed excellent (i) cytocompatibility, and (ii) intracellular uptake in the cancer (HepG2 liver & MCF-7 breast) cells for the incubation periods of 24/48 h. Thus, the TETA-TEG coated SPIONs based aqueous ferrofluids have a great potential to be used in biomedical applications. (C) 2018 Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to ELSEVIER SCIENCE BV
Keywords: Functionalized SPIONs; Polyamines; Polyols; Aqueous Ferrofluids; Cytocompatibility
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Id for Latest eprints
Date Deposited: 27 Feb 2019 09:22
Last Modified: 27 Feb 2019 09:22
URI: http://eprints.iisc.ac.in/id/eprint/61837

Actions (login required)

View Item View Item