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The Foreign Body Response Demystified

Chandorkar, Yashoda and Ravikumar, K and Basu, Bikramjit (2019) The Foreign Body Response Demystified. In: ACS BIOMATERIALS SCIENCE & ENGINEERING, 5 (1, SI). pp. 19-44.

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Official URL: https://doi.org/10.1021/acsbiomaterials.8b00252

Abstract

The human body is endowed with an uncanny ability to distinguish self from foreign. The implantation of a foreign object inside a mammalian host activates complex signaling cascades, which lead to biological encapsulation of the implant. This reaction by the host system to a foreign object is known as foreign body response (FBR). Over the last few decades, it has been increasingly important to have a deeper insight into the mechanisms of FBR is needed to develop biomaterials for better integration with living systems. In the light of recent advances in tissue engineering and regenerative medicine, particularly in the field of biosensors and biodegradable tissue engineering scaffolds, the classical concepts related to the FBR have acquired new dimensions. The aim of this review is to provide a holistic view of the FBR, while critically analyzing the challenges, which need to be addressed in the future to overcome this innate response. In particular, this review discusses the relevant experimental methodology to assess the host response. The role of erosion and degradation behavior on FBR with biodegradable polymers is largely explored. Apart from the discussion on temporal progression of FBR, an emphasis has been given to the design of next-generation biomaterials with favorable host response.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to AMER CHEMICAL SOC
Keywords: foreign body response; nonspecific protein adsorption; antifouling polymers; polymer degradation and erosion
Department/Centre: Division of Chemical Sciences > Materials Research Centre
Division of Interdisciplinary Research > Centre for Biosystems Science and Engineering
Depositing User: Id for Latest eprints
Date Deposited: 15 Feb 2019 08:57
Last Modified: 15 Feb 2019 08:57
URI: http://eprints.iisc.ac.in/id/eprint/61722

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