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Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates

Dixit, Jyotsana and Zachariah, Arun and Sajesh, PK and Chandramohan, Bathrachalam and Shanmuganatham, Vinoth and Karanth, Praveen K (2018) Reinvestigating the status of malaria parasite (Plasmodium sp.) in Indian non-human primates. In: PLOS NEGLECTED TROPICAL DISEASES, 12 (12).

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Official URL: https://doi.org/10.1371/journal.pntd.0006801

Abstract

Many human parasites and pathogens have closely related counterparts among non-human primates. For example, non-human primates harbour several species of malaria causing parasites of the genus Plasmodium. Studies suggest that for a better understanding of the origin and evolution of human malaria parasites it is important to know the diversity and evolutionary relationships of these parasites in non-human primates. Much work has been undertaken on malaria parasites in wild great Apes of Africa as well as wild monkeys of Southeast Asia however studies are lacking from South Asia, particularly India. India is one of the major malaria prone regions in the world and exhibits high primate diversity which in turn provides ideal setting for both zoonoses and anthropozoonoses. In this study we report the molecular data for malaria parasites from wild populations of Indian non-human primates. We surveyed 349 fecal samples from five different Indian non-human primates, while 94 blood and tissue samples from one of the Indian non-human primate species (Macaca radiata) and one blood sample from M. mulatta. Our results confirm the presence of P. fragile, P. inui and P. cynomolgi in Macaca radiata. Additionally, we report for the first time the presence of human malarial parasite, P. falciparum, in M. mulatta and M. radiata. Additionally, our results indicate that M. radiata does not exhibit population structure probably due to human mediated translocation of problem monkeys. Human mediated transport of macaques adds an additional level of complexity to tacking malaria in human. This issue has implications for both the spread of primate as well as human specific malarias.

Item Type: Journal Article
Additional Information: Copyright of this article belongs toPUBLIC LIBRARY SCIENCE
Department/Centre: Division of Biological Sciences > Centre for Ecological Sciences
Depositing User: Id for Latest eprints
Date Deposited: 06 Feb 2019 06:02
Last Modified: 06 Feb 2019 06:02
URI: http://eprints.iisc.ac.in/id/eprint/61599

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