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Induction of MHC-I and thymic depletion due to replication of JEV in mouse brain

Kavitha, Y and Manjunath, R (2004) Induction of MHC-I and thymic depletion due to replication of JEV in mouse brain. In: Archives of Virology, 149 (11). pp. 2079-2093.

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The thymus is a primary lymphoid organ that is responsible for T cell development and maturation.Thymic depletion accompanied by apoptosis and altered T cell maturation occurs during several viral infections. Here we show that adult mice intracerebrally infected with Japanese encephalitis virus exhibit severe cell depletion and alterations in the $CD4^+$ and $CD8^+$ single as well as $CD4^+CD8^+$ double positive cell populations. A 5.6 fold induction of MHC-I but not MHC-II was observed on thymocytes of such mice and was accompanied with a progressive depletion of thymocytes as the disease progressed with 90% of double positives being depleted by 9 days post infection. Staining studies with propidium iodide and AnnexinV revealed that the percent thymocytes undergoing apoptosis had increased significantly in animals infected with Japanese encephalitis virus. Although similar changes in MHC-I expression were also observed in newborn pups challenged with Japanese encephalitis virus, qualitative and quantitative differences in thymocyte depletion were observed relative to the adult thymus. These observations may have implications in the ability of the immune system to respond to specific antigens and possible autoimmunity in survivors of Japanese encephalitis infection.

Item Type: Journal Article
Publication: Archives of Virology
Publisher: Springer
Additional Information: The copyright of this article belongs to Springer.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 25 Aug 2008
Last Modified: 19 Sep 2010 04:25
URI: http://eprints.iisc.ac.in/id/eprint/6154

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