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An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer

Asampille, Gitanjali and Verma, Brijesh Kumar and Swain, Monalisa and Shettar, Abhijith and Rosenzweig, Steven A and Kondaiah, Paturu and Atreya, Hanudatta S (2018) An ultra-stable redox-controlled self-assembling polypeptide nanotube for targeted imaging and therapy in cancer. In: JOURNAL OF NANOBIOTECHNOLOGY, 16 .

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Official URL: https://doi.org/10.1186/s12951-018-0427-1

Abstract

We introduce a self-assembling polypeptide-based nanotube system having the ability to specifically target cancer cells. The nanotubes target the cancer cell surface through integrin engagement with the help of multiple RGD units present along their surface. While the nanotubes are non-toxic towards cells in general, they can be loaded with suitable drugs to be released in a sustained manner in cancer cells. In addition, the nanotubes can be utilized for cellular imaging using any covalently tagged fluorescent dye. They are stable over a wide range of temperature due to intermolecular disulphide bonds formed during the self-assembly process. At the same time, presence of disulphide bonds provides a redox molecular switch for their degradation. Taken together this system provides a unique avenue for multimodal formulation in cancer therapy.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to JOURNAL OF NANOBIOTECHNOLOGY
Keywords: Protein nanotube; Self-assembly; Intermolecular disulfide bonds; RGD motif; Integrin targeting; Cancer
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > NMR Research Centre (Formerly Sophisticated Instruments Facility)
Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Depositing User: Francis Jayakanth
Date Deposited: 10 Feb 2019 09:37
Last Modified: 10 Feb 2019 09:37
URI: http://eprints.iisc.ac.in/id/eprint/61357

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