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Rh(iii)-Catalyzed ortho-C-(sp(2))-H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis

Hande, Akshay Ekanath and Ramesh, Vinay Bapu and Prabhu, Kandikere Ramaiah (2018) Rh(iii)-Catalyzed ortho-C-(sp(2))-H amidation of ketones and aldehydes under synergistic ligand-accelerated catalysis. In: CHEMICAL COMMUNICATIONS, 54 (85). pp. 12113-12116.

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Official URL: http://dx.doi.org/ 10.1039/c8cc07006g

Abstract

Rh(iii)-Catalyzed ortho-C-H amidation of ketones and aldehydes under cooperative metal organocatalysis has been utilized for synthesizing various ortho-amidocarbonyl analogs, and the reaction for the aldehyde proceeds at ambient temperature. The aniline derivative 3,5-bis(trifluoromethyl)aniline promotes the amidation reaction via a transient imine directing group. The efficient amidation agent is dioxazolone. The synthetic utility has been demonstrated in the synthesis of quindolinone alkaloids.

Item Type: Journal Article
Additional Information: Copy right for this article belong to ROYAL SOC CHEMISTRY
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 12 Nov 2018 15:43
Last Modified: 12 Nov 2018 15:43
URI: http://eprints.iisc.ac.in/id/eprint/61019

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