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Photochemotherapy of Infrared Active BODIPY-Appended Iron(III) Catecholates for in Vivo Tumor Growth Inhibition

Garai, Aditya and Gandhi, Armin and Ramu, Vanitha and Raza, Md Kausar and Kondaiah, Paturu and Chakravarty, Akhil R (2018) Photochemotherapy of Infrared Active BODIPY-Appended Iron(III) Catecholates for in Vivo Tumor Growth Inhibition. In: ACS OMEGA, 3 (8). pp. 9333-9338.

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Official URL: http://dx.doi.org/10.1021/acsomega.8b01001

Abstract

Iron(III) catecholates of BODIPY (boron dipyrromethene)-conjugated dipicolylamine ligands, viz. Fe (L-1)(cat)Cl] (1) and Fe(L-2)(cat)Cl] (2) (H(2)cat = catechol), with a ligand-to-metal charge transfer band at similar to 800 nm were studied for their in vivo activity in dark and infrared light in luciferase-expressing human breast adenocarcinoma (BT474luc) cells. Complex 2 displayed in vitro photo cytotoxicity in BT474luc cells (IC50: 6 mu M) in infrared light nm of 600-720 nm with moderate dark toxicity (IC50: 18 mu M) as evidenced from the MTT and Annexin-V FITC/PI staining assays: The mitochondria-localizing complexes showed apoptotic cell death involving reactive oxygen species whose generation was evidenced from 2,7-dichlorofluorescein diacetate assay. In vivo studies showed tumor growth inhibition in mice with an optimized complex 2 dose of 5 mg per kg body weight on exposure to infrared light of 685 nm (dose of 20 mW/cm(2)). The in vivo results exemplify complex 2 as a unique iron based infrared active photochemotherapeutic agent.

Item Type: Journal Article
Additional Information: Copy right for this article belong to AMER CHEMICAL SOC
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 18 Oct 2018 13:09
Last Modified: 18 Oct 2018 13:09
URI: http://eprints.iisc.ac.in/id/eprint/60909

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