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The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets

NaveenKumar, Somanathapura K and SharathBabu, Bidare N and Hemshekhar, Mahadevappa and Kemparaju, Kempaiah and Girish, Kesturu S and Mugesh, Govindasamy (2018) The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets. In: ACS CHEMICAL BIOLOGY, 13 (8). pp. 1996-2002.

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Official URL: http://dx.doi.org/10.1021/acschembio.8b00458

Abstract

Hemolysis, a process by which the destruction of red blood cells leads to the release of hemoglobin, is a critical event observed during hemolytic disorders. Under oxidative stress conditions, hemoglobin can release its heme prosthetic group, which is highly cytotoxic and can catalyze the generation of reactive oxygen species (ROS), leading to several undesired redox reactions in the cells. Herein, we demonstrate for the first time that heme can mediate the activation and death of human platelets through ferroptosis, which is an iron-dependent form of nonapoptotic cell death. This study also suggests that the heme-mediated lipid peroxidation and ferroptosis in platelets may play an important role in hemolytic disorders.

Item Type: Journal Article
Additional Information: Copy right for this article belong to AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 25 Sep 2018 17:31
Last Modified: 25 Sep 2018 17:31
URI: http://eprints.iisc.ac.in/id/eprint/60713

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