Scratching the Surface of an Itch: Molecular Evolution of Aculeata Venom Allergens

Baumann, Kate and Dashevsky, Daniel and Sunagar, Kartik and Fry, Bryan (2018) Scratching the Surface of an Itch: Molecular Evolution of Aculeata Venom Allergens. In: JOURNAL OF MOLECULAR EVOLUTION, 86 (7). pp. 484-500.

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Abstract

Hymenopteran insects are infamous for their sting, and their ability to cause severe anaphylaxis and in some cases death. This allergic reaction is a result of allergens present in the venom. Hymenopterans have many common venom allergens, the most widespread of which include phospholipase A(1), phospholipase A(2), acid phosphatase, hyaluronidase, serine protease and antigen 5. While there have been studies that look at the phylogenetic histories of allergens within closely related species, to our knowledge, this is the first study using evolutionary analyses to compare across Hymenoptera the types of selection that are occurring on allergens. This research examined the publicly available sequences of six different groups of allergens and found that allergens had diverged and formed closely related clades which share greater sequence similarities. We also analysed the patterns of selection and found that they are predominately under the influence of negative selection.

Item Type:	Journal Article
Publication:	JOURNAL OF MOLECULAR EVOLUTION
Publisher:	SPRINGER
Additional Information:	The Copyright for this article belong to Springer New York LLC.
Keywords:	Venom evolution; Toxin; Hymenoptera; Allergen
Department/Centre:	Division of Biological Sciences > Centre for Ecological Sciences
Date Deposited:	25 Sep 2018 17:31
Last Modified:	02 Aug 2022 10:52
URI:	https://eprints.iisc.ac.in/id/eprint/60709

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