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Early assessment of bulk powder processability as a part of solid form screening

Upadhyay, Pratik P and Pudasaini, Nawin and Mishra, Manish Kumar and Ramamurty, Upadrasta and Rantanen, Jukka (2018) Early assessment of bulk powder processability as a part of solid form screening. In: CHEMICAL ENGINEERING RESEARCH & DESIGN, 136 . pp. 447-455.

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Official URL: http://dx.doi.org/10.1016/j.cherd.2018.05.020

Abstract

A systematic assessment of key material attributes of active pharmaceutical ingredients (APIs) using minimal material approach is illustrated at the particulate level and bulk level. At a bulk level, flowability improvement of an API through crystal habit manipulation is exemplified. The impact of crystal structures and particulate properties (crystal habit and crystal size) on their mechanical behaviour were addressed by measuring powder tabletability. Bulk powder flow and tabletability were assessed on a small scale using ring shear tester and using a single punch compaction simulator, which can be easily integrated during the process of solid form screening activity for early preformulation studies. In addition, mechanical responses on single crystals were evaluated with nanoindentation. Indentation performed on three faces of piroxicam single crystals resulted reproducible results when compared with the literature, indicating the efficiency of this technique to perform single crystal characterization. The study highlights that, the early assessment of key material properties during solid form screening can aid in selecting optimal solid forms provided physicochemical properties are acceptable. (C) 2018 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

Item Type: Journal Article
Additional Information: Copy right for this article belong to INST CHEMICAL ENGINEERS, 165-189 RAILWAY TERRACE, DAVIS BLDG, RUGBY CV21 3HQ, ENGLAND
Keywords: Solid form screening; Powder flow; Tabletability; Nanoindentation; Piroxicam; 5-Aminosalicylic acid
Department/Centre: Division of Chemical Sciences > Solid State & Structural Chemistry Unit
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Id for Latest eprints
Date Deposited: 12 Sep 2018 15:17
Last Modified: 12 Sep 2018 15:17
URI: http://eprints.iisc.ac.in/id/eprint/60663

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