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Smart optical probe for `equipment-free' detection of oxalate in biological fluids and plant-derived food items

Dey, Nilanjan and Kumari, Namita and Bhagat, Deepa and Bhattacharya, Santanu (2018) Smart optical probe for `equipment-free' detection of oxalate in biological fluids and plant-derived food items. In: TETRAHEDRON, 74 (34). pp. 4457-4465.

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Official URL: http://dx.doi.org/10.1016/j.tet.2018.06.052

Abstract

A reversible `turn-on' sensor has been designed for `naked-eye' detection of oxalate at nanomolar concentration (similar to 12.5 nM) at pH 7.4. The sensory system shows a highly specific response towards oxalate among a wide range of antinutrients and biologically relevant anionic species. Mechanistic investigations indicate that oxalate can turn the pink-colored solution colorless by dissociating the preformed metal complex. Additionally, high specificity and good accuracy with recovery values ranging from 93.3 to 105.0% were obtained during oxalate estimation in spiked water and human urine samples, confirming the suitability of the present method in estimating trace-level of oxalate in complex matrices. With these results, quantitative estimations of endogenous oxalate were achieved in more than twenty-five different agricultural crops. Finally, low-cost, portable paper strips were developed for on-site detection of oxalate. (C) 2018 Published by Elsevier Ltd.

Item Type: Journal Article
Additional Information: Copy right for this article belong to PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 06 Sep 2018 15:42
Last Modified: 06 Sep 2018 15:42
URI: http://eprints.iisc.ac.in/id/eprint/60580

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