Suppressor of clathrin deficiency (Scd6)An emerging RGG-motif translation repressor

Roy, Debadrita and Rajyaguru, Purusharth I (2018) Suppressor of clathrin deficiency (Scd6)An emerging RGG-motif translation repressor. In: WILEY INTERDISCIPLINARY REVIEWS-RNA, 9 (5).

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Abstract

Translation control plays a key role in variety of cellular processes. Translation initiation factors augment translation, whereas translation repressor proteins inhibit translation. Different repressors act by distinct mechanisms to accomplish the repression process. Although messenger RNAs (mRNAs) can be repressed at various steps of translation, most repressors have been reported to target the initiation step. We focus on one such translation repressor, an Arginine-Glycine-Glycine (RGG)-motif containing protein Scd6. Using this protein as a model, we present a discourse on the known and possible functions of this repressor, its mechanism of action and its recently reported regulation. We suggest a case for conservation of the mechanism employed by Scd6 along with its regulation in orthologs, and propose that Scd6 family of proteins will be an ideal tool to understand translation control and mRNA fate decision mechanisms across biological systems. This article is categorized under: Translation > Translation Regulation RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes

Item Type:	Journal Article
Publication:	WILEY INTERDISCIPLINARY REVIEWS-RNA
Additional Information:	Copy right for this article belong to WILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Department/Centre:	Division of Biological Sciences > Biochemistry
Date Deposited:	06 Sep 2018 15:43
Last Modified:	04 Oct 2018 15:16
URI:	http://eprints.iisc.ac.in/id/eprint/60578

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