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N-Heterocyclic Carbene-Catalyzed Synthesis of alpha-Trifluoromethyl Esters

Gelat, Fabien and Patra, Atanu and Pannecoucke, Xavier and Biju, Akkattu T and Poisson, Thomas and Besset, Tatiana (2018) N-Heterocyclic Carbene-Catalyzed Synthesis of alpha-Trifluoromethyl Esters. In: ORGANIC LETTERS, 20 (13). pp. 3897-3901.

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Official URL: https://dx.doi.org/10.1021/acs.orglett.8b01482

Abstract

The N-heterocyclic carbene (NHC)-catalyzed trifluoromethylation of alpha-chloro aldehydes was developed, allowing straightforward access to valuable alpha-trifluoromethyl ester derivatives. The unique combination of an electrophilic trifluoromethylation reagent with NHC catalysis was the key for the functionalization of a broad range of alpha-chloro aldehydes, and the products are formed in moderate to good yields. Investigations of the enantioselective version of this reaction afforded the enantioenriched products in moderate yields with good ee values.

Item Type: Journal Article
Additional Information: Copyright of this article belong to AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 31 Jul 2018 15:28
Last Modified: 31 Jul 2018 15:28
URI: http://eprints.iisc.ac.in/id/eprint/60331

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