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The Remarkable Effect of Halogen Substitution on the Membrane Transport of Fluorescent Molecules in Living Cells

Ungati, Harinarayana and Govindaraj, Vijayakumar and Mugesh, Govindasamy (2018) The Remarkable Effect of Halogen Substitution on the Membrane Transport of Fluorescent Molecules in Living Cells. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 57 (29). pp. 8989-8993.

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Official URL: https://dx.doi.org/10.3389/fmicb.2018.01632

Abstract

Small-molecule-based fluorescent probes have become important tools in biology for sensing and imaging applications. However, the biological applications of many of the fluorescent molecules are hampered by low cellular uptake and high toxicity. In this paper, we show for the first time that the introduction of halogen atoms enhances the cellular uptake of fluorescent molecules and the nature of halogen atoms plays a crucial role in the plasma membrane transport in mammalian cells. The remarkably higher uptake of iodinated compounds compared to that of their chloro or bromo analogues suggests that the strong halogen bonding ability of iodine atoms may play an important role in the membrane transport. This study provides a novel strategy for the transport of fluorescent molecules across the plasma membrane in living cells.

Item Type: Journal Article
Publication: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Publisher: Wiley-VCH Verlag
Additional Information: The Copyright of this article belong to Wiley-VCH Verlag.
Keywords: cellular uptake; fluorescent molecules; halogens; MCT8 transporter; thyroid hormones
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 31 Jul 2018 15:28
Last Modified: 03 Aug 2022 04:55
URI: https://eprints.iisc.ac.in/id/eprint/60323

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