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Hydrogen bond surrogate stabilized water soluble 3(10)-helix from a disordered pentapeptide containing coded alpha-amino acids

Pal, Sunit and Prabhakaran, Erode N (2018) Hydrogen bond surrogate stabilized water soluble 3(10)-helix from a disordered pentapeptide containing coded alpha-amino acids. In: TETRAHEDRON LETTERS, 59 (26). pp. 2515-2519.

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Official URL: https://dx.doi.org/ 10.1016/j.tetlet.2018.05.029

Abstract

Replacing a hypothetical i + 3 -> i peptide H-bond in a disordered pentapeptide, that lacks any helicogenic C-alpha-tetrasubstituted residues, with a propyl linker and carbamylating the N-terminal nitrogen constrains it in the elusive 3(10)-helical structure with high helicity and stability under varying conditions of temperature and pH, confirmed by NMR and CD analyses. (C) 2018 Elsevier Ltd. All rights reserved.

Item Type: Journal Article
Additional Information: Copyright of this article belong to PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 19 Jul 2018 14:54
Last Modified: 19 Jul 2018 14:54
URI: http://eprints.iisc.ac.in/id/eprint/60242

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