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Coordination-driven self-assembly of ruthenium(II) architectures: synthesis, characterization and cytotoxicity studies

Adeyemo, Aderonke Ajibola and Shettar, Abhijith and Bhat, Imtiyaz Ahmad and Kondaiah, Paturu and Mukherjee, Partha Sarathi (2018) Coordination-driven self-assembly of ruthenium(II) architectures: synthesis, characterization and cytotoxicity studies. In: DALTON TRANSACTIONS, 47 (25). pp. 8466-8475.

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Official URL: https://dx.doi.org/10.1039/c8dt00962g

Abstract

Coordination-driven self-assembly of organometallic eta(6)-arene ruthenium(ii) supramolecular architectures (MA(1)-MA(4)) was carried out by employing dinuclear ruthenium acceptors Ru-2(mu-eta(4)-C2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-a), Ru-2(mu-eta(4)-C6H2O4)(CH3OH)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-b), Ru-2(dhnq)(H2O)(2)(eta(6)-p-cymene)(2)](CF3SO3)(2) (Ru-c) and Ru-2(dhtq)(H2O)(2)((6)-p-cymene)(2)](CF3SO3)(2) (Ru-d) separately with a new tetratopic donor (TD) in methanol at room temperature TD = N,N,N,N-tetra(pyridin-4-yl)-1,1-biphenyl]-4,4-diamine]. All the coordination architectures were characterized by using spectroscopic techniques. The potency of these self-assembled architectures against human cervical cancer HeLa and human lung adenocarcinoma A549 cell lines is explored in vitro using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), annexin V-FITC/PI and 2,7-dichlorofluorescein-diacetate assays.

Item Type: Journal Article
Additional Information: Copyright of this article belong to ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Biological Sciences > Molecular Reproduction, Development & Genetics
Division of Chemical Sciences > Inorganic & Physical Chemistry
Depositing User: Id for Latest eprints
Date Deposited: 18 Jul 2018 15:41
Last Modified: 18 Jul 2018 15:41
URI: http://eprints.iisc.ac.in/id/eprint/60228

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