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Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection

Bulagonda, Eswarappa Pradeep and Manivannan, Bhavani and Mahalingam, Niranjana and Lama, Manmath and Chanakya, Pachi Pulusu and Khamari, Balaram and Jadhao, Sudhir and Vasudevan, Madavan and Nagaraja, Valakunja (2018) Comparative genomic analysis of a naturally competent Elizabethkingia anophelis isolated from an eye infection. In: SCIENTIFIC REPORTS, 8 .

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Official URL: https://dx.doi.org/10.1038/s41598-018-26874-8

Abstract

Elizabethkingia anophelis has now emerged as an opportunistic human pathogen. However, its mechanisms of transmission remain unexplained. Comparative genomic (CG) analysis of E. anopheles endophthalmitis strain surprisingly found from an eye infection patient with twenty-five other E. anophelis genomes revealed its potential to participate in horizontal gene transfer. CG analysis revealed that the study isolate has an open pan genome and has undergone extensive gene rearrangements. We demonstrate that the strain is naturally competent, hitherto not reported in any members of Elizabethkingia. Presence of competence related genes, mobile genetic elements, Type IV, VI secretory systems and a unique virulence factor arylsulfatase suggests a different lineage of the strain. Deciphering the genome of E. anophelis having a reservoir of antibiotic resistance genes and virulence factors associated with diverse human infections may open up avenues to deal with the myriad of its human infections and devise strategies to combat the pathogen.

Item Type: Journal Article
Additional Information: Copy right of this article belong to NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Depositing User: Id for Latest eprints
Date Deposited: 18 Jun 2018 15:44
Last Modified: 18 Jun 2018 15:44
URI: http://eprints.iisc.ac.in/id/eprint/60040

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