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Neutrophils at the Biological-Material Interface

Jhunjhunwala, Siddharth (2018) Neutrophils at the Biological-Material Interface. In: ACS BIOMATERIALS SCIENCE & ENGINEERING, 4 (4, SI). pp. 1128-1136.

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Official URL: http://dx.doi.org/ 10.1021/acsbiomaterials.6b00743


Integral to the development of new biomaterials is the characterization of immune responses to biomaterial implants, and formulating methods to overcome or utilize these actions for therapeutic benefit. Neutrophils are an essential component of the immune response against biomaterials, but studies on the neutrophil biomaterial interaction have been largely limited to characterizing their role in establishing an inflammatory microenvironment and antimicrobial activity at implant surfaces. Recent advances in neutrophil biology, especially recognition of their cellular heterogeneity, ability to suppress immune responses, the identification of a new process of cell death, and crosstalk with other immune cell types, have brought about a fundamental change in our perception regarding the activities of neutrophils. Herein, in the context of the progress in our comprehension of neutrophil function, potential avenues for effectively employing neutrophil activity to develop the next generation of regenerative biomaterials are discussed.

Item Type: Journal Article
Additional Information: Copy right for this article belong to AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Interdisciplinary Research > Centre for Biosystems Science and Engineering
Depositing User: Id for Latest eprints
Date Deposited: 04 May 2018 18:48
Last Modified: 23 Oct 2018 14:48
URI: http://eprints.iisc.ac.in/id/eprint/59742

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