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Immunohistochemical evaluation of prime molecules in cervical lesions towards assessment of malignant potentiality

Das, Lopamudra and Naskar, Sukla and Sarkar, Tandra and Maiti, Ashok Kumar and Das, Soumen and Chatterjee, Jyotirmoy (2018) Immunohistochemical evaluation of prime molecules in cervical lesions towards assessment of malignant potentiality. In: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 14 (2). pp. 377-381.

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Official URL: http://dx.doi.org/10.4103/0973-1482.158029


Objective: A comparative immunohistochemical evaluation of p63, CD105, and E-cadherin expression pattern in histopathologically confirmed normal cervical epithelium (NCM), dysplastic cervical epithelium (DYS) and squamous cell carcinoma (SCC) of uterine cervix towards assessing malignant potentiality of the precancerous condition. Materials and Methods: The biopsies from cervical mucosa (normal, dysplasia, and cancer) were studied by routine hematoxylin and eosin (H and E) and by immunohistochemistry for p63, E-cadherin, and CD105 expression. The expressions of these molecules were assessed in a semiquantitative way by (i) counting p63 cell population and distribution, (ii) intensity scoring of E-cadherin along the expression path, and (iii) measuring CD105 expression density. Result: p63+ cells were highest in carcinomas followed by dysplasia and normal. An abrupt increase in CD105 expression was observed through change of normal to dysplasia and cancer. A decrease in membranous E-cadherin expression was noticed in the transformation from normal to precancer and cancers. Conclusion: The malignant potential of the dysplastic conditions is likely to be correlated with upregulation in p63 and CD105 expression and a simultaneous downregulation of membranous E-cadherin.

Item Type: Journal Article
Additional Information: Copy right for the article belong to MEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA
Department/Centre: Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Depositing User: Id for Latest eprints
Date Deposited: 13 Apr 2018 19:57
Last Modified: 13 Apr 2018 19:57
URI: http://eprints.iisc.ac.in/id/eprint/59547

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